Second-Look Ultrasound Post Contrast-Enhanced Mammography for Additional Lesions Characterization

Graziella di Grezia

Status: Invitation-only

Conditions: Breast Cancer Detection; Breast Cancer Diagnosis

Treatments: Diagnostic Test: CEM protocol

Study type: Observational

Funder types: Other

Identifiers

NCT06846814

T_4_2025

Details and patient eligibility

About

This study investigates the utility of second-look ultrasound (US) following contrast-enhanced mammography (CEM) to characterize additional lesions detected during routine breast imaging.

Full description

The goal is to assess the diagnostic accuracy and clinical value of combining CEM with targeted ultrasound to improve lesion characterization and guide biopsy decisions.

Enrollment: 350 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing contrast-enhanced mammography for diagnostic or surveillance purposes.
• Identification of additional lesions on CEM requiring further evaluation.
• Ability to provide informed consent.

Exclusion criteria

• Known breast cancer diagnosis without suspicion of additional lesions.
• Contraindications to ultrasound or contrast agents.
• Patients with incomplete imaging data.