Second Transplantation for Graft Failure

Peking University

Status: Unknown

Conditions: Graft Failure; Stem Cell Transplant Complications

Treatments: Other: second allogeneic stem cell transplantation

Study type: Interventional

Funder types: Other

Identifiers

NCT03717545

2nd tx for GF

Details and patient eligibility

About

Graft failure is a lethal complication after allogeneic stem cell transplantation, which often need a salvage transplantation. However, the current outcome of second transplantation for graft failure is far from satisfactory. We performed a prospective single-arm study to investigate the safety and efficacy of a novel regimen.

Enrollment: 12 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• graft failure after first allogeneic stem cell transplantation
• no active infection or GVHD or severe organ dysfunction
• sign written informed consent

Exclusion criteria

• active infection, GVHD, organ failure
• expected life < 28 days

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

intervention arm

Experimental group

Description:

second allogeneic stem cell transplantation

Treatment:

Other: second allogeneic stem cell transplantation