Secondary Prevention in Type 2 Diabetes: Comparison of Two Different Resistance Exercise Training Protocols

Paracelsus Medical University (PMU)

Status and phase: Completed; Phase 1

Conditions: Type 2 Diabetes Mellitus

Treatments: Other: Physical exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT01218256

UISM-2-2010

Details and patient eligibility

About

Skeletal muscle accounts for up to 40% of the total body weight and is responsible for approximately 75% of the whole body insulin-stimulated glucose uptake. Resistance training has been shown to improve insulin-stimulated glucose uptake in patients with T2DM. Therefore the investigators aim to compose the effects of 2 different resistance training protocols in combination with aerobic endurance training (AET) on muscle strength, muscle mass and glycemic control in type 2 diabetes mellitus patients (T2DM).

The investigators aim to perform an 8 week randomized controlled training intervention in 32 T2DM patients. Patients will be randomly assigned to AET (cycle ergometer, 60-70% of heart rate reserve) combined with hypertrophy resistance training (HRT, n=16, 2 sets, 10-12 repetitions, 70% of the one-repetition maximum) or with endurance resistance training (ERT, n=16, 2 sets, 25-30 repetitions, 40% of the one-repetition maximum). Body composition, blood analyses, physical work capacity and muscle strength will be measured pre- and post-intervention.

Enrollment: 32 patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• type 2 diabetes mellitus

Exclusion criteria

• myocardial infarction within the last 6 months
• unstable angina pectoris
• left ventricular ejection fraction less than 40%
• orthopedic limitations that eliminate to perform resistance training

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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32 participants in 2 patient groups

Hypertrophy resistance training

Active Comparator group

Description:

Aerobic endurance training combined with hypertrophy resistance training in type 2 diabetes mellitus.

Treatment:

Other: Physical exercise training

Endurance resistance training

Active Comparator group

Description:

Aerobic endurance training combined with hypertrophy resistance training in type 2 diabetes mellitus.

Treatment:

Other: Physical exercise training