Secondhand Smoking in Asthmatic Children

AHEPA University Hospital

Status: Completed

Conditions: Wheezing; Asthma in Children

Treatments: Diagnostic Test: White blood cell DNA extraction; Diagnostic Test: Lung function; Diagnostic Test: Urinary testing

Study type: Observational

Funder types: Other

Identifiers

NCT03099902

14/1-3-2011

Details and patient eligibility

About

This study will investigate the interaction between GSTP1 / TNFa polymorphisms and passive smoking in children with asthma/wheezing. Contemporary second hand-smoke exposure will be confirmed by laboratory testing.

Enrollment: 90 patients

Sex: All

Ages: 12 months to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subjects 1-18 years old with doctor diagnosed asthma/wheezing

Exclusion criteria

• Premature birth (< 36 gestation weeks)
• Asthma-like symptoms due to other conditions (infectious, congenital, mechanical)

Trial design

90 participants in 2 patient groups

Cases

Description:

Children with asthma/wheezing whose mothers were active smokers during pregnancy

Treatment:

Diagnostic Test: White blood cell DNA extraction

Diagnostic Test: Lung function

Diagnostic Test: Urinary testing

Controls

Description:

Children without asthma/wheezing whose mothers were active smokers during pregnancy

Treatment:

Diagnostic Test: White blood cell DNA extraction

Diagnostic Test: Lung function

Diagnostic Test: Urinary testing