Efficacy of Dexmedetomidine vs Midazolam for Early Extubation in Critically Ill Agitated Patients Undergoing Weaning

Sheikh Zayed Medical College

Status and phase: Not yet enrolling; Early Phase 1

Conditions: Agitation, Emergence

Treatments: Drug: Dexmedetomidine Hydrochloride

Study type: Interventional

Funder types: Other

Identifiers

NCT05264077

MJKhan

Details and patient eligibility

About

Comparison of effect of dexmedetomidine and midazolam in icu patients who put on mechanical ventilation and show agitation on weaning.Selection of better agent minimises the drug related side effects like respiratory depression but also helps in weaning for early extubation,give hemodynamic stability and reduce morbidity and mortality in icu..

Enrollment: 66 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• all patients with age <60 irrespective of gendre

Exclusion criteria

• Patients who refuse to give consent, severely altered conscious level (GCS < 8/15), traumatic injury causing hypoxemia e.g., severe head / chest / facial trauma or pneumothorax, severe pneumonia, arrhythmia, impaired hearing or blindness, severe hepatic or renal disease, on neuromuscular blocking agents, recent myocardial infarction, use of anti-psychotics, hypersensitivity to any of the drug under study.

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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66 participants in 2 patient groups

Dexmedetomidine

Experimental group

Description:

Inj.Dexmedetomidine(precidex ) 200mcg/2ml Given to participants in infusion form for 24 hours

Treatment:

Drug: Dexmedetomidine Hydrochloride

Midazolam

Experimental group

Description:

Inj.midazolam 5mg/ml given to participants in infusion form for 24 hrs

Treatment:

Drug: Dexmedetomidine Hydrochloride