Sedation and Ease of Weaning From Mechanical Ventilation

Assiut University

Status: Completed

Conditions: Weaning Failure; Respiratory Failure; Chronic Obstructive Pulmonary Disease; Midazolam Overdose

Treatments: Drug: Daily interruption of midazolam

Study type: Interventional

Funder types: Other

Identifiers

NCT03406936

IRB00009917

Details and patient eligibility

About

Daily interruption of sedation is one of the modalities which is known to enhance early weaning and separation from mechanical ventilation . Daily sedation interruption is also known to help decreasing incidence of ventilator associated pneumonia. The new modality is no sedation.

Full description

there is an increase of incidence of chronic obstructive lung disease associated respiratory failure which necessitates invasive mechanical ventilation. It is well known that one of the bundles for enhanced recovery of such cases is the daily interruption of sedation . Recently studies have demonstrated the feasibility of just using sedation for initiation of mechanical ventilation, then utilization of no sedation technique as a more this offers less side effects .

Enrollment: 100 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Obstructive lung disease
• Respiratory failure
• Invasive mechanical ventilation

Exclusion criteria

• Neurological deficit
• Cognitive dysfunction
• Extensive malignancy
• septic Shock

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Daily interruption of sedation

Active Comparator group

Description:

Daily interruption of sedation will be done at 7 am daily by stoppage of midazolam infusion

Treatment:

Drug: Daily interruption of midazolam

No Sedation

No Intervention group

Description:

No sedation will be given after initiation of mechanical ventilation