Sedation and Pain (The Effect of IV Sedation on Pain Perception)

The University of Alabama at Birmingham

Status

Completed

Conditions

Pain

Treatments

Drug: propofol

Drug: dexmedetomidine

Drug: midazolam

Study type

Interventional

Funder types

Other

Identifiers

NCT00853333

F081016014

Details and patient eligibility

About

The investigators propose to evaluate the potential effect of sedation on pain perception in two ways, by asking for a participant's pain rating(subjective) and by evaluating a subject's brain activation using fMRI(objective).

Full description

We propose to contrast and compare the effect of propofol and midazolam, two GABA-related sedative drugs, and dexmedetomidine, an alpha-2 adrenergic agonist, on pain perception in human volunteers by asking a participant to rate their pain and by evaluating a subject's brain activation using fMRI.

Enrollment

86 patients

Sex

All

Ages

19 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy subjects

19 years or older able to follow study instructions

Exclusion criteria

Age less than 19 or greater than 40
Pregnant female
Obesity (BMI > or =35)
Non-English speaking/reading participants
Sleep apnea
Pulmonary problems such as moderate or severe bronchial asthma
Cardiovascular problems such as hypertension
History of claustrophobia
Presence of a pacemaker, defibrillator, surgically placed metallic object (e.g., hip replacement)or other implanted device
Presence of an unremoved bullet or shrapnel in the body
Presence of a prosthetic that is not removable
Presence of a hearing aid needed for hearing
Head girth exceeding that of the head coil used in the magnet
Extensive metalwork on or in teeth, or irremovable false teeth or bridgework
Epilepsy
Chronic analgesic medication
Excessive tattoos (due to local skin heating with tattoos containing ferromagnetic particles)
History of surgery for which details are unavailable
Allery due to study drugs
History of drug abuse