Sedation by Dexmedetomidine and Propofol

Seoul National University

Status: Completed

Conditions: Anesthesia, Spinal

Treatments: Drug: Dexmedetomidine; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT02993718

WatchPAT

Details and patient eligibility

About

Under the hypothesis that dexmedetomidine sedation would result in less upper airway obstruction, we evaluated the occurrence of upper airway collapse or the requirement of airway intervention in patients with obstructive sleep apnea during dexmedetomidine or propofol sedation.

Enrollment: 52 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Surgery under spinal anesthesia
• Intraoperative sedation
• American Society of Anesthesiology physical status 1 or 2
• Apnea/hypopnea index 5-14/h in Watch-PAT 200 analysis

Exclusion criteria

• Anatomical defects on upper respiratory tract
• Psychotic disorder
• Drug addition
• Alcohol addition
• body mass index ≥ 35 kg/m2

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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52 participants in 2 patient groups

Dexmedetomidine

Experimental group

Description:

Intraoperative sedation is performed by using dexmedetomidine.

Treatment:

Drug: Dexmedetomidine

Propofol

Experimental group

Description:

Intraoperative sedation is performed by using propofol

Treatment:

Drug: Propofol