Sedation During Microelectrode Recordings Before Deep Brain Stimulation for Movement Disorders.

Hadassah Medical Center

Status: Unknown

Conditions: Tourette Syndrome; Parkinsonian Disorders; Dystonia; Parkinson Disease; Movement Disorders

Treatments: Procedure: Sedation with IV propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT00355927

HTA3769

DBSsed1-HMO-CTIL

Details and patient eligibility

About

The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.

Full description

Deep Brain Stimulation is commonly used for the treatment of movement disorders. Electrode positioning is usually performed under local anesthesia in fully awake patients. The procedure is uncomfortable to the patients who have to remain motionless during the whole surgery. Previous reports of electrode positioning under general anesthesia was found to be less accurate. This result was probably due to the effect of the anesthetics on the electrical activity of the Basal Ganglia.

The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to propofol sedation. Electrical activity of single neurons will be recorded before and after sedation.

Enrollment: 20 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Candidate for Deep Brain Stimulation Surgery.
• Informed concent obtained.

Exclusion criteria

• Suspected difficult intubation (by history or physical examination).
• Allergy to Propofol, eggs or soy-beans.
• History of sleep apnea syndrome.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)