Sedation for Upper Gastrointestinal Endoscopy in Pediatric Patients

Ain Shams University

Status and phase: Completed; Phase 4

Conditions: Upper Gastrointestinal Endoscopy

Treatments: Drug: Dexmedetomidine-ketamine; Drug: propofol-ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT02863861

FMASU R 12/2016

Details and patient eligibility

About

The purpose of this study is to compere between Propofol-Ketamine combination and Dexmedetomidine-Ketamine combination for sedation in upper gastrointestinal endoscopy in paediatric patients.

Enrollment: 120 patients

Sex: All

Ages: 2 to 7 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists ASA I-II patients aging 2-7 years.

Exclusion criteria

known allergy to any of the study drugs, significant cardiovascular disease vomiting.

Trial design

120 participants in 2 patient groups

Group PK

Experimental group

Description:

Propofol-Ketamine group: patients in this group will receive IV ketamine at a dose of 1mg.kg-1 in addition to IV propofol 1mg.kg-1 for induction with added doses of propofol 1mg.kg-1 when needed.

Treatment:

Drug: propofol-ketamine

Group DK

Experimental group

Description:

Dexmedetomidine-Ketamine group: patients in this group will receive IV ketamine at a dose of 1mg.kg-1 in addition to IV dexmedetomidine 0.5 mcg.kg-1 for induction with additional doses of dexmedetomidine 0.5mcg.kg-1 when required

Treatment:

Drug: Dexmedetomidine-ketamine