Sedation Strategies for Therapeutic Bronchoscopy 2

Naval Military Medical University

Status: Unknown

Conditions: Sedation; Bronchoscopy

Treatments: Drug: Dexmedetomidine; Device: Laryngeal mask; Drug: Remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT03983915

SED-TFB2

Details and patient eligibility

About

Therapeutic bronchoscopy is a common procedure to treat respiratory diseases. The procedure includes stent implantation, bronchus dilation, electronic incision, laser therapy, and so on. Most of these procedures are painful and require general anesthesia. Conventionally, the general anesthesia for therapeutic bronchoscopy was performed using laryngeal mask. But in the previous experiences, the investigators found that sedation with dexmedetomidine and remifentanil was as effect as laryngeal mask anesthesia. The present study was performed to compare the two approach for sedation or anesthesia in therapeutic bronchoscopy.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Scheduled for flexible therapeutic bronchoscopy
• Adult patients aged 18 to 65 years
• American Society of Anesthesiologists (ASA) Physical Status Classification I-II
• BMI 18.5-25kg/m2
• Subjects provide informed consent

Exclusion criteria

• Severe airway obstruction
• Coagulation disorder
• Repeat bronchoscopy (more than 3 times)
• Severe liver and renal dysfunction
• Cardiovascular and cerebrovascular diseases
• Pregnancy
• Chronic opioid user
• Drug abusers or addicts

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

Group DR

Experimental group

Description:

Patients sedated with dexmedetomidine and remifentanil.

Treatment:

Drug: Remifentanil

Drug: Dexmedetomidine

Group LMA

Experimental group

Description:

General anesthesia was applied using laryngeal mask.

Treatment:

Device: Laryngeal mask