Sedation to Electroencephalography With Dexmedetomidine or Chloral Hydrate

Federal University of Minas Gerais

Status and phase: Completed; Phase 3

Conditions: Other Conditions of Brain

Treatments: Drug: Dexmedetomidine; Drug: Chloral Hydrate

Study type: Interventional

Funder types: Other

Identifiers

NCT01083797

CEP 106/2009

Details and patient eligibility

About

This study evaluates the use of dexmedetomidine or chloral hydrate for sedation during electroencephalography in patients with neurological disorders. The hypothesis is that this drugs provides similar changes in EEG pattern.

Full description

Patients with chronic neurological disorders such as cerebral palsy or autism need to be sedated during electroencephalography (EEG). However, various sedatives and hypnotics affect the outcome of the review and is not shown. Chloral hydrate (CH) is widely used in children, but in this patients it is less effective.Recently, dexmedetomidine (DEX) has been tested because preliminary data suggests that this drug does not affect the EEG. The aim of the present work was to compare the electroencephalogram (EEG) pattern during CH or DEX sedation, to test the hypothesis that both drugs exert similar effects in EEG.Seventeen patients were evaluated during sedation with DEX or CH on separate occasions.The EEG was subjected to qualitative and quantitative analysis. Clinical variables were also compared.

Enrollment: 25 patients

Sex: All

Ages: 12 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• neurological disorder
• behavior disorder
• epilepsy

Exclusion criteria

• cardiac disease
• respiratory disease

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

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25 participants in 1 patient group

dexmedetomidine, chloral hydrate

Other group

Description:

sedation with dexmedetomidine or chloral hydrate on separate occasions in the same patients

Treatment:

Drug: Chloral Hydrate

Drug: Dexmedetomidine