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Sedation With Remimazolam During Spinal Anesthesia

Y

Yonsei University Health System (YUHS)

Status

Completed

Conditions

Spinal Anesthesia
Sedation

Treatments

Drug: Dexmedetomidine
Drug: Remimazolam

Study type

Interventional

Funder types

Other

Identifiers

NCT05305248
3-2021-0489

Details and patient eligibility

About

Remimazolam is a benzodiazepine-binding site antagonist of the GABA receptor, metabolized by esterases, and exhibits a stable context-sensitive half-life of 6-7 minutes. Remimazolam has a high clearance rate and a small volume of distribution in the pharmacokinetic model. The US FDA has approved sedation for surgery. Although there have been studies on the use of remimazolam as a sedative for procedures such as endoscopy, there have been no reports of the use of remimazolam in spinal anesthesia. The purpose of this study is to compare and analyze the hemodynamics and recovery profile of patients undergoing surgery under spinal anesthesia by maintaining sedation with dexmedetomidine or remimazolam.

Enrollment

62 patients

Sex

All

Ages

19+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Severe cardiovascular or respiratory disease
  2. Contraindication to spinal anesthesia
  3. Heart block
  4. Previous hepatectomy or liver transplant
  5. Patients with moderate or more hepatic impairment (AST/ALT is more than 2.5 times the upper limit of normal)
  6. Estimated glomerular filtration rate < 30 mL/min/1.73m2
  7. Acute narrow angle glaucoma
  8. Myasthesia gravis
  9. Known allergy to the drugs included in the study

Exclusion criteria

  1. Patients 19 years of age or older who are expected to elective orthopedic surgery under spinal anaesthesia
  2. ASA PS 1-3

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

62 participants in 2 patient groups

Remimazolam group
Experimental group
Description:
Sedation with remimazolam during spinal anesthesia
Treatment:
Drug: Remimazolam
Dexmedetomidine group
Active Comparator group
Description:
Sedation with dexmedetomidine during spinal anesthesia
Treatment:
Drug: Dexmedetomidine

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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