SEGATROM: Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition

German Institute of Human Nutrition

Status: Completed

Conditions: Disorder of Glucose Regulation

Treatments: Dietary Supplement: bitter block; Dietary Supplement: sweet block; Dietary Supplement: umami-block; Other: gastroscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT02219295

BMBF 11005D

Details and patient eligibility

About

We investigate the impact of taste receptors (sweet, bitter and umami) on human metabolism. There ist growing evidence, that components of the taste signalling system, including the taste receptor proteins , have important functions in the regulation of metabolic parameters in non-gustatory tissues.

Full description

We apply different sweet, bitter and umami taste compounds in a single dose in the human intervention. We use substances as for instance glucose, sucrose,saccharin and lactisol in the sweet part, and substances from cabbage, beer or red endive in the bitter part. For umami we take glutamate.

Blood samples are collected at baseline and 6 times thereafter up to 3hours, to analyse the incretins GLP-1(glucagon-like peptide 1) and GIP(gastrointestinal polypeptide) and other peptide hormones as insulin and PYY(peptide tyrosin trosin) in human beings.

Gastrointestinal mucosa is taken by gastroscopy from the lower duodenum from study subjects for analysis for the presence or absence of functional taste receptors in gastrointestinal tissues.

Enrollment: 97 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy persons

Exclusion criteria

• Tumor in history
• Pregnancy
• Severe illness in history
• Bodymass index below 18

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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97 participants in 4 patient groups

sweet -block

Experimental group

Description:

application of different sugars, artificial sweeteners and sweet-taste antagonists in a single dose in 300 ml tap water every week up to 7 times and collection of blood samples over 3 hours

Treatment:

Dietary Supplement: umami-block

Dietary Supplement: sweet block

Dietary Supplement: bitter block

bitter block

Experimental group

Description:

application of purified bitter tasting ingredients of vegetables and hop in 300 ml tap water , collection of blood samples for 3h (-15,0,15,30,60,120,180 min)

Treatment:

Dietary Supplement: umami-block

Dietary Supplement: sweet block

Dietary Supplement: bitter block

umami-block

Experimental group

Description:

application of glutamate and glutamate +IMP same procedure as above

Treatment:

Dietary Supplement: umami-block

Dietary Supplement: sweet block

Dietary Supplement: bitter block

gastroscopy

Other group

Description:

gastroscopy with and without oral intervention with artificial sweetener saccharin to take tissue samples from the upper bowel for the investigation of taste receptor cells in the upper bowel in human beings

Treatment:

Other: gastroscopy