Segmentectomy vs Lobectomy

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Active, not recruiting

Conditions: Surgery; Non-small Cell Lung Cancer Stage I

Study type: Observational

Funder types: Other

Identifiers

NCT06180239

6146

Details and patient eligibility

About

Actual indications for stage Ia NSCLC patients suggest lobectomy and lymphadenectomy. On the other hand, recent studies reported non-inferiority of segmentectomy in case of nodule < 2cm or with ground glass appearance at computed tomography.

However, most of these studies did not report specifical analysis on kind of segmentectomy (single or multiple) and kind of lobectomy. Moreover, a specific study on solid nodules only is still missing.

For these reasons, the effectiveness of segmentectomy instead lobectomy for every kind of segment or tumor is still to be defined.

Aim of this study is to analyze survival outcome in patients underwent single or multiple segmentectomy compared to lobectomy in stage I non small cell lung cancer.

Enrollment: 800 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adenocarcinoma or squamous cell carcinoma
• cStage cIA with or without nodal upstaging
• lymphoadenectomy
• age > 18 years old
• Radical resection
• anatomical resection (lobectomy or segmentectomy)
• PET CT done

Exclusion criteria

• Nodal or distant metastasis confirmed before surgery
• Pure solid GGO
• Follow up < 12 months
• Bilobectomy/pneumonectomy
• Trans fissure tumor
• Multiple lung tumors

Trial design

800 participants in 3 patient groups

Single Segmentectomy group

Description:

patients underwent single segment resection,

Lobectomy group

Description:

Patients underwent lobectomy

Multiple segmentectomy group

Description:

patients underwent multiple segments resection,