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Seizure Control as a New Metric in Assessing Efficacy of Tumor Treatment in Patients With Low Grade Glioma

M.D. Anderson Cancer Center logo

M.D. Anderson Cancer Center

Status

Active, not recruiting

Conditions

Low Grade Glioma
Brain Neoplasm
Seizure Disorder

Treatments

Other: Survey Administration

Study type

Observational

Funder types

Other
NIH

Identifiers

NCT04553757
NCI-2020-06510 (Registry Identifier)
2020-0124 (Other Identifier)

Details and patient eligibility

About

This study investigates how seizures can vary over time with changes in low grade gliomas and its treatments. This study may help doctors find symptoms or triggers of seizures earlier than normal, and ultimately earlier care or treatment for seizures.

Full description

PRIMARY OBJECTIVE:

I. To evaluate the rate of change of seizure frequency and the status of the tumor at each data collection point.

SECONDARY OBJECTIVES:

I. To obtain sufficient number of patients' data in order to power the analysis to determine whether a change in seizure frequency correlates with tumor control.

II. Evaluate progression free survival and overall survival when compared with seizure control.

OUTLINE:

Patients complete a seizure assessment survey over 5 minutes at each clinic visit.

Enrollment

100 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Adult patients
  • Primary brain tumors (separated by World Health Organization [WHO] grade I-IV)
  • History of seizures secondary to brain tumor
  • On tumor directed treatment
  • Magnetic resonance imaging (MRI) within 2 weeks of clinic visit where seizure assessment takes place

Exclusion criteria

  • Patients without seizures
  • Patients with intracranial lesions other than primary brain tumor
  • Patients not undergoing tumor directed treatment
  • Absence of recent (within 2 weeks) MRI

Trial design

100 participants in 1 patient group

Observational (survey)
Description:
Patients complete a seizure assessment survey over 5 minutes at each clinic visit.
Treatment:
Other: Survey Administration

Trial contacts and locations

1

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Central trial contact

Ashley Aaroe, MD

Data sourced from clinicaltrials.gov

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