Selection of Antibiotic Resistance by Azithromycin and Clarithromycin in the Oral Flora

Universiteit Antwerpen

Status: Completed

Conditions: Healthy Volunteers

Treatments: Drug: Macrolides (azithromycin or clarithromycin)

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00354952

UA-Med Micro-2002

Details and patient eligibility

About

Resistance to antibiotics is a major public-health problem and studies linking antibiotic use and resistance have shown an association not a causal effect. Utilizing the newer macrolides, azithromycin and clarithromycin that are commonly prescribed for respiratory infections, we investigated the direct impact of antibiotic exposure on resistance at the individual level.

Full description

Resistance to antibiotics is a major public-health problem and studies linking antibiotic use and resistance have shown an association not a causal effect. Utilizing the newer macrolides, azithromycin and clarithromycin that are commonly prescribed for respiratory infections, we investigated the direct impact of antibiotic exposure on resistance at the individual level. 203 healthy cohorts were treated with azithromycin, clarithromycin, or a placebo in a randomised, double-blind trial. Pharyngeal swabs were collected pre- (day 0) and post-antibiotic administration (days 8, 14, 28, 42, 180) and proportions of macrolide-resistant streptococci (MRS) were determined at each time-point.

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy adults (≥ 18 years of age)
• non-pregnant
• free of any respiratory tract infection
• not having been administered any antibiotic at least in the past three months

Exclusion criteria

• <18 years of age
• pregnant
• having a respiratory tract infection
• having been administered any antibiotic at least in the past three months

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind