Selective Extended Dissection in Different Types of Pancreatic Head Cancer: A Retrospective Cohort Study.

Tianjin Medical University

Status: Completed

Conditions: Carcinoma, Pancreatic Ductal

Treatments: Procedure: Selective extended dissection of pancreaticoduodenectomy

Study type: Observational

Funder types: Other

Identifiers

NCT05723978

Panc-2023129

Details and patient eligibility

About

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with relatively poor survival. Surgery is the first choice for the treatment of patients with early pancreatic cancer. However, the surgical approach and the extent of resection for patients with pancreatic cancer are controversial at present.

The investigators optimized the procedure of standard pancreaticoduodenectomy to selective extended dissection (SED), which is based on the extra-pancreatic nerve plexus (PLX) potentially invaded by tumor. The investigators retrospectively analyzed the clinicopathological data of patients with pancreatic adenocarcinoma who underwent radical surgery in our center from 2011 to 2020. Patients who underwent standard dissection (SD) were matched 2:1 to those who underwent SED using propensity score matching (PSM). The log-rank test and cox regression model were used to analyze survival data. In addition, statistical analyses were performed for the perioperative complications, postoperative pathology and recurrence pattern.

Enrollment: 520 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Patients diagnosed as resectable pancreatic cancer were pathologically diagnosed as PDAC after surgery.

2. Patients received radical surgery (R0) and had complete photos or videos of the operation.

Exclusion criteria

• 1. The operation records as well as related photo or video data could not reflect the surgical approach and the extent of resection.

2. Patients with incomplete clinical, pathological, imaging and follow-up information.

Trial design

520 participants in 2 patient groups

Selective extended dissection (SED) group

Treatment:

Procedure: Selective extended dissection of pancreaticoduodenectomy

Standard dissection (SD) group