Selenium and Ischemic Stroke Outcome

Mazandaran University of Medical Sciences

Status: Completed

Conditions: Ischemic Stroke

Treatments: Dietary Supplement: Selenium; Drug: normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT02505295

1421

Details and patient eligibility

About

Selenium is a trace element essential to human health.Selenium protection against cellular damage by oxygen radicals is accomplished through selenoproteins. Ischemic stroke is associated with the generation of oxygen free radicals resulting in a condition of oxidative stress. Supplementing stroke patients with antioxidant nutrients may improve survival.

Enrollment: 44 patients

Sex: All

Ages: 20 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Accepted ischemic stroke by brain CT or MRI during last 72 h
2. Ischemic stroke in Middle Cerebral Artery territory
3. Volume of stroke at list one third of MCA territory
4. written informed consent.

Exclusion criteria

1. Known allergy to selenium
2. Severe renal failure( cr clearance under 50 ml/min or serum cr upper than 2
3. Severe hepatic failure( total bill upper than 2 or ALT/AST 5 time upper than normal limit)
4. Severe neurodegenerative disease such as severe dementia, alzheimer and Parkinson
5. Pregnancy or lactation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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44 participants in 2 patient groups, including a placebo group

selenium

Active Comparator group

Description:

vial selenium (selenase 500 microgr ) 2000 microgram stat and 1000 microgram daily for 5 days

Treatment:

Dietary Supplement: Selenium

normal saline

Placebo Comparator group

Description:

40 cc normal saline stat and 20 cc daily for 5 days( in vials like selenase vial)

Treatment:

Drug: normal saline