Selenium Levels in Patients With Abdominal Aneurysm

Comenius University

Status: Active, not recruiting

Conditions: Abdominal Aneurysm; Selenium Deficiency

Study type: Observational

Funder types: Other

Identifiers

NCT07236281

EK 1/11/2024

Details and patient eligibility

About

Retrospective study comparing the selenium level in patients with abdominal aortic aneurysm with the selenium level in patients in the control group, i.e., patients without aneurysmal changes of the abdominal aorta.

Full description

Selenium (Se), incorporated into selenocysteine, is an essential component of selenoproteins. These proteins play a crucial role in vascular protection by reducing oxidative stress, regulating inflammation, supporting endothelial nitric oxide signalling, and maintaining smooth muscle cell homeostasis. Insufficient selenoprotein activity contributes to vascular dysfunction and weakening of the vessel wall.

The aim of this project is to investigate a potential association between reduced selenium levels and abdominal aortic aneurysm (AAA) of degenerative origin.

The study group will include 20 individuals with an abdominal aortic aneurysm measuring at least 35 millimeters in diameter, verified by a radiologist using standard diagnostic imaging methods (ultrasound, CT angiography, or digital subtraction angiography). The control group will comprise 20 individuals without an abdominal aortic aneurysm. Selenium blood levels will be measured in both groups, and the relationship between selenium status and the presence of AAA will be evaluated using biostatistical analysis.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• cases - patients with AAA (confirmed by radiology) followed by vascular surgery outpatient office that signed informed consent. The AAA was not treated by surgery or endovascular intervention
• controls - people without AAA (confirmed by ultrasonography) followed by vascular surgery outpatient office for other vascular disease that signed informed consent

Exclusion criteria

• patients that had AAA treated by surgery or endovascular intervention
• persons that did not sign informed consent

Trial design

40 participants in 2 patient groups

Cases - persons with abdominal aortic aneurysm

Description:

Persons with abdominal aortic aneurysm (AAA) of minimally 35 mm diameter, followed by vascular surgery outpatient office. AAA is verified by radiology, was not treated by surgical or endovascular intervention.

Controls - persons without abdominal aortic aneurysm

Description:

Persons without abdominal aortic aneurysm (AAA), as confirmed by ultrasonography. Controls will be recruited from vascular surgery outpatient office, in treatment for other vascular conditions.