Selenium Status Measured in Blood After a Higher Intake of Fish and Shellfish - a Randomized Dietary Intervention Study

Danish Cancer Society

Status and phase

Completed

Phase 1

Conditions

Selenium Status

Selenium Uptake From Fish and Shellfish

Treatments

Dietary Supplement: Fish and shellfish

Study type

Interventional

Funder types

Other

Identifiers

NCT01224249

DCS-53227244

Details and patient eligibility

About

The primary aim of this study is to investigate, whether higher intake of selenium rich food items such as fish and shellfish, is associated with higher selenium blood levels.

The secondary aim is to investigate the uptake of selenium from fish and shellfish and the incorporation of selenium from those foods into proteins in the human body. Furthermore, the impact of the natural variation in the genes that are responsible for the accumulation of selenium in the proteins will be investigated.

Full description

Selenium is an essential trace element that is incorporated into proteins in the human body and it hereby plays a major role in several important cellular processes. Previous studies have indicated that the selenium status of the Danish population is below the levels required to optimize the suggested protective effects of selenium towards major diseases including cancer. In Denmark, important natural sources of selenium are fish and shellfish.

Enrollment

102 patients

Sex

All

Ages

50 to 74 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

men and women
50-74 years
BMI 18.5-28 kg/m2
non-smokers

Exclusion criteria

strenuous exercise > 10 h/week
excessive intake of alcohol
frequent intake of fish and shellfish > 200-300 g/week
intake of dietary supplements 3 months before or during the study
frequent use of medication except antihypertensive medicine, cholesterol lowering medicine and hormone replacement medicine
simultaneous participation in other research projects
cancer diagnosis within the past 5 years
severe chronic diseases