Self-consciousness in Dementia

University Hospital, Strasbourg, France

Status: Unknown

Conditions: Alzheimer Disease; Fronto-temporal Lobar Dementia

Treatments: Other: Questionnary and IRM

Study type: Interventional

Funder types: Other

Identifiers

NCT01782248

5289 (Other Identifier)

Details and patient eligibility

About

The aim of this study is to characterize the deficit in critical components of personal identity (self-consciousness and social cognition) in patients with Alzheimer's disease (AD) and fronto-temporal lobar dementia (FTLD), compared to healthy elderly, combining a neuropsychology and multi-podal neuroimaging study.

We posit that the alteration of some aspects of self-consciousness (autobiographical memory, nosognosia, metacognition) and social cognition (theory of mind and facial) results in personality changes in the patients, primarily due to the alteration of self-consciousness in AD and to social cognition in FTLD.

Enrollment: 65 estimated patients

Sex: All

Ages: 45 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• AD (McKhann et al, 1984 and Dubois et al, 2007) or FTLD (Neary et al, 1998 or Rascovsky et al, 2011)
• MMSE > or = 18
• Relative avaible

Exclusion criteria

• Contraindication to MRI
• Major depression
• Other central neurological condition

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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65 participants in 3 patient groups

Alzheimer disease

Other group

Description:

Patients with Alzheimer disease

Treatment:

Other: Questionnary and IRM

Fronto-temporal lobar dementia

Other group

Description:

Patients with Fronto-temporal lobar dementia

Treatment:

Other: Questionnary and IRM

Control

Other group

Description:

Control group

Treatment:

Other: Questionnary and IRM