Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) Study

Mass General Brigham

Status: Completed

Conditions: Major Depression; Bipolar Disorder; Rumination

Treatments: Other: Functional Magnetic Resonance Imaging (fMRI)

Study type: Observational

Funder types: Other

Identifiers

NCT02253225

2012P000714

19531 (Other Grant/Funding Number)

Details and patient eligibility

About

The investigators propose to examine both resting state activity and functional activity during rumination and during self-processing to study the relationship between neural correlates of rumination/self-focus and self-processing in major depression and bipolar disorder.

Full description

Negative rumination, a specific form of self-focus, characterized by repetitively focusing on one's symptoms of distress, and the possible causes and consequences of these symptoms, is a hallmark of depression. Nearly a decade of research has culminated in evidence that the tendency to engage in negative rumination is highly correlated with depressive symptoms. Rumination also plays a critical role in the etiology and maintenance of depressed states and predicts risk for mania in bipolar disorder. Despite the central role of rumination in major depression and bipolar disorder, there have been few studies to date investigating the functional neuroanatomy of negative rumination, and no studies of positive rumination. The few neuroimaging studies that have utilized measures of the tendency to engage in negative rumination have focused on brain functioning when performing tasks that involve processing emotional or self-referential stimuli, but they have not studied resting state activity or functional activity during negative and positive rumination. We are examining both resting state activity and functional activity during negative and positive rumination and during self-processing to study the relationship between the neural correlates of rumination/self-focus and self-processing in major depression and bipolar disorder.

Enrollment: 32 patients

Sex: All

Ages: 18 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria Healthy Controls:

• Right-handed (as determined by the Handedness Inventory; Oldfield, 1971)
• Normal or corrected-to normal vision and hearing

Exclusion Criteria for Healthy Controls:

• Any current or past psychiatric history
• Significant medical, psychiatric or neurological illness
• Currently taking antidepressants, mood stabilizers, or benzodiazepines
• Positive MR screen (e.g., metal implant, claustrophobia, etc)

Inclusion Criteria for Patients with Major Depression:

• Current diagnosis of MDD
• Right-handed (as determined by the Handedness Inventory; Oldfield, 1971)
• Normal or corrected-to normal vision and hearing

Exclusion Criteria for MDD Patients:

• If a history of substance abuse, at least 6 months in remission
• Current suicidal ideation or history of suicide attempts
• Positive MR screen (e.g., metal implant, claustrophobia, etc)

Inclusion Criteria for patients with BPAD:

• Current diagnosis of BPAD
• Right-handed (as determined by the Handedness Inventory; Oldfield, 1971)
• Normal or corrected-to normal vision and hearing

Exclusion Criteria for BPAD Patients:

• If a history of substance abuse, at least 6 months in remission
• Current suicidal ideation or history of suicide attempts
• Positive MR screen (e.g., metal implant, claustrophobia, etc)

Trial design

32 participants in 3 patient groups

Bipolar Disorder

Description:

Clinical status will be determined using the Mini International Neuropsychiatric Interview (M.I.N.I) for 20 patients with bipolar disorder (BPAD).

Treatment:

Other: Functional Magnetic Resonance Imaging (fMRI)

Major Depressive Disorder

Description:

Clinical status will be determined using the Mini International Neuropsychiatric Interview (M.I.N.I) for 20 patients with major depression (MDD).

Treatment:

Other: Functional Magnetic Resonance Imaging (fMRI)

Healthy Control

Description:

Clinical status will be determined using the Mini International Neuropsychiatric Interview (M.I.N.I) for 20 normal, healthy volunteers.

Treatment:

Other: Functional Magnetic Resonance Imaging (fMRI)