Semantic Memory, Financial Capacity, and Brain Perfusion in Mild Cognitive Impairment (MCI) (CASL)

VA Office of Research and Development

Status: Completed

Conditions: Alzheimer Disease; Dementia

Study type: Observational

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT00880555

E6553-W

Details and patient eligibility

About

Alzheimer's disease (AD) often manifests as a memory disorder before dementia develops. Dementia is considered to be present when a person can no longer handle complex activities of daily living, such as managing finances. This study will investigate the relationship between changes in the ability to manage finances and brain perfusion, which will be measured using continuous arterial spin-labeling (an experimental MRI). Subjects will also undergo neuropsychological tests focusing on several types of memory and thought process, with special emphasis on semantic memory. An important question to be addressed is whether changes in function are better predicted by the neuropsychological tests or by the brain scan.

Full description

Alzheimer's disease (AD) often manifests as a memory disorder before dementia develops. Dementia is considered to be present when a person can no longer handle complex activities of daily living, such as managing finances. This study will investigate the relationship between changes in the ability to manage finances and brain perfusion, which will be measured using continuous arterial spin-labeling (an experimental MRI). Subjects will also undergo neuropsychological tests focusing on several types of memory and thought process, with special emphasis on semantic memory. An important question to be addressed is whether changes in function are better predicted by the neuropsychological tests or by the brain scan. Participants will undergo a single MRI scan, baseline financial capacity instrument (FCI) and cognitive evaluation, and then will be followed approximately annually to repeat the functional and cognitive assessments. Linear mixed effects models will be used to fit a model predicting financial capacity based on baseline cognitive tests. Measures from the MRI scan will be added to the model to determine whether imaging improves the predictions.

Enrollment: 78 patients

Sex: All

Ages: 50 to 89 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Veteran or non-veteran
• Age 50-89
• With normal cognition or memory impairment (MCI or mild AD)
• English speaking
• Right handed
• Adequate vision and hearing to take part in tests
• Able and willing to undergo MRI scan
• Medically and psychiatrically stable
• No other brain disease (such as tumor, Parkinson's disease, major stroke)

Exclusion criteria

• Pregnancy
• Inability to tolerate MRI (due to metal in body or claustrophobia)

Trial design

78 participants in 3 patient groups

Arm 1: Non-Dementia Memory Disorder

Description:

Elderly patients with non-dementia memory disorder (mild cognitive impairment)

Arm 2: Control

Description:

Elderly controls without memory impairment

Arm 3: Mild Alzheimer Disease

Description:

Patients with mild Alzheimer disease (but preserved routine activities of daily living)