Semantic Memory, Financial Capacity, and Brain Perfusion in Mild Cognitive Impairment (MCI) (CASL)

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VA Office of Research and Development

Status

Completed

Conditions

Alzheimer Disease
Dementia

Study type

Observational

Funder types

Other
Other U.S. Federal agency

Identifiers

NCT00880555
E6553-W

Details and patient eligibility

About

Alzheimer's disease (AD) often manifests as a memory disorder before dementia develops. Dementia is considered to be present when a person can no longer handle complex activities of daily living, such as managing finances. This study will investigate the relationship between changes in the ability to manage finances and brain perfusion, which will be measured using continuous arterial spin-labeling (an experimental MRI). Subjects will also undergo neuropsychological tests focusing on several types of memory and thought process, with special emphasis on semantic memory. An important question to be addressed is whether changes in function are better predicted by the neuropsychological tests or by the brain scan.

Full description

Alzheimer's disease (AD) often manifests as a memory disorder before dementia develops. Dementia is considered to be present when a person can no longer handle complex activities of daily living, such as managing finances. This study will investigate the relationship between changes in the ability to manage finances and brain perfusion, which will be measured using continuous arterial spin-labeling (an experimental MRI). Subjects will also undergo neuropsychological tests focusing on several types of memory and thought process, with special emphasis on semantic memory. An important question to be addressed is whether changes in function are better predicted by the neuropsychological tests or by the brain scan. Participants will undergo a single MRI scan, baseline financial capacity instrument (FCI) and cognitive evaluation, and then will be followed approximately annually to repeat the functional and cognitive assessments. Linear mixed effects models will be used to fit a model predicting financial capacity based on baseline cognitive tests. Measures from the MRI scan will be added to the model to determine whether imaging improves the predictions.

Enrollment

78 patients

Sex

All

Ages

50 to 89 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Veteran or non-veteran
  • Age 50-89
  • With normal cognition or memory impairment (MCI or mild AD)
  • English speaking
  • Right handed
  • Adequate vision and hearing to take part in tests
  • Able and willing to undergo MRI scan
  • Medically and psychiatrically stable
  • No other brain disease (such as tumor, Parkinson's disease, major stroke)

Exclusion criteria

  • Pregnancy
  • Inability to tolerate MRI (due to metal in body or claustrophobia)

Trial design

78 participants in 3 patient groups

Arm 1: Non-Dementia Memory Disorder
Description:
Elderly patients with non-dementia memory disorder (mild cognitive impairment)
Arm 2: Control
Description:
Elderly controls without memory impairment
Arm 3: Mild Alzheimer Disease
Description:
Patients with mild Alzheimer disease (but preserved routine activities of daily living)

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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