Semi-automated Segmentation Methods of SSTR PET for Dosimetry Prediction (177Lumen)

Central Hospital, Nancy, France

Status: Completed

Conditions: Refractory Meningioma

Treatments: Other: To evaluate the SUVmean (Standard Uptake Value) as a predictive factor of the tumor absorbed dose compared to the SUVmax

Study type: Observational

Funder types: Other

Identifiers

NCT05537675

2022PI

Details and patient eligibility

About

Tumor dosimetry with somatostatin receptor-targeted peptide receptor radionuclide therapy (SSTR-targeted PRRT) by 177Lutetium-DOTATATE might contribute to improve follow-up and treatment response of refractory meningiomas. This study aims to evaluate Standard Uptake Value mean (SUVmean) as a tumoral absorbed dose predictive predictive factor and propose semi-automated segmentation method to determine metabolic tumor volume with pretherapeutic 68-Gallium-DOTATOC PET.

Enrollment: 20 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with meningioma

Exclusion criteria

• PET scan not available

Trial design

20 participants in 2 patient groups

20 patients with meningioma

Description:

20 meningioma patients will be included in this study, 10 of whom will have been treated with Lutathera®.

Treatment:

Other: To evaluate the SUVmean (Standard Uptake Value) as a predictive factor of the tumor absorbed dose compared to the SUVmax

10 patients will have been treated with Lutathera®.

Description:

10 patients of the 20 will have been treated with Lutathera®.

Treatment:

Other: To evaluate the SUVmean (Standard Uptake Value) as a predictive factor of the tumor absorbed dose compared to the SUVmax