Semi-manual Vessel Density Analysis on Optical Coherence Tomography Angiography Images of Healthy Adults

Semmelweis University

Status: Completed

Conditions: Healthy

Treatments: Device: Optical coherence tomography angiography (Zeiss Cirrus HD OCT 5000 AngioPlex)

Study type: Observational

Funder types: Other

Identifiers

NCT03590899

VESDEN-OCTA-1253

Details and patient eligibility

About

Purpose of the study is to examine the vessel density of healthy adults' optical coherence tomography angiography images with two semi-manual methods and an automated quantification program.

Full description

Optical coherence tomography angiography (OCTA) is a software upgrade on conventional spectral-domain or swept-source optical coherence tomography devices that enables non-invasive, dye-free, three dimensional analysis of the retinal vessels.

Vessel density is a very important parameter almost in all retinal disorders. In the recent past, automated quantification software was built into some OCTA devices which can automatically calculate the retinal vessel density as well.

In this study two semi-manual techniques are used in order to analyze the vessel density of healthy subjects' OCTA images. Vessel density is also measured with a new automated quantification program, and results of the three methods are compared.

OCT machines are approved in the EU and the US and are not experimental devices.

The device used in this study is the commercially available Zeiss Cirrus HD OCT Angioplex 5000 that operates with spectral-domain technology.

Enrollment: 39 patients

Sex: All

Ages: 18 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy patients without eye disease

Exclusion criteria

• incapacity
• any history or clinical evidence of retinal disease or glaucoma
• previous ocular surgery or laser photocoagulation
• optical media opacities that would disturb imaging

Trial design

39 participants in 1 patient group

Healthy patients

Description:

Healthy volunteers without retinal disease, glaucoma, previous ocular surgery, laser photocoagulation, or optical media opacities that would disturb imaging.

Treatment:

Device: Optical coherence tomography angiography (Zeiss Cirrus HD OCT 5000 AngioPlex)