Sensitivity and Specificity of Leucocytes Subpopulation Versus Platelet Indices in Prediction of Clinical Outcome for Candidates With Sepsis. A Bi-centric Observational Clinical Trial

Minia University

Status: Not yet enrolling

Conditions: Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT06612307

Anet 19-2

Details and patient eligibility

About

Leucocyte subpopulation and platelet indices analysis can predict clinical outcome

Enrollment: 161 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult population of both sex, aged 20 or older admitted to the ICU with a diagnosis of sepsis were screened for inclusion within 48 h of presentation to the hospital. Sepsis was defined as per the Sepsis-3 definition, 6 ie, the presence of suspected or documented infection with organ dysfunction determined by an acute increase of sequential organ failure assessment (SOFA) score by 2 or more points

Exclusion criteria

• Patient refusal.
• History of surgery in the last 7 days from admission.
• Immunocompromised population ( post-transplantation, steroid use > 5 mg per day, malignancy, HIV, on chemotherapy).
• Population with history of thrombocytopenia ( ITP, aplastic anemia, drug induced)
• History of thrombocytosis ( idiopathic thrombocytosis, post-splenectomy)
• History of platelet transfusion one week before admission.
• Bone marrow transplanted population .
• Chronic liver and kidney disease.
• Von-Willebrand disease.
• Patients on antiplatelet therapy ( Aspirin, clopidogrel).
• Thrombocytopenic population ( ITP, TTP,HELLP) .
• Myelodysplastic or proliferative patients.
• Blood dyscarsiasis
• Obestetric parturients.