Sensitivity Comparison of Follow-up MRI Between Acute Cerebral and Cerebellar Cortical Microinfarctions ( CMI )Microinfarctions

Centre Hospitalier Universitaire de Nīmes

Status: Enrolling

Conditions: Acute Cerebral and Cerebellar Cortical Microinfarctions (CMI)

Treatments: Other: None, purely observational study

Study type: Observational

Funder types: Other

Identifiers

NCT06218576

LOCAL/2023/DR-01

Details and patient eligibility

About

Cerebral cortical microinfarctions (CMI) are frequently observed on MRI and histology studies, especially in elderly patients and in patients with cognitive dysfunction. The majority of these studies analysed chronic cerebral CMI lesions.

The few studies reporting on temporal dynamics of MRI signal of acute cerebral CMI showed very low sensibility for persisting signal changes on follow-up MRI on standard MRI sequences. A retrospective study, analysing follow-up 3T MRI in 25 patients with acute cerebral CMI (defined as ≤10 mm on DWI), showed a chronic cerebral CMI detection rate of only 16% on T2-weighted and 5% on FLAIR imaging after a mean follow-up period of 33 months (with a very wide range of 0.5-142 months). Another 3T MRI study including seven patients showed disappearance of all acute cerebral very small-sized CMI (defined as <5 mm size on initial DWI) on all follow-up MRI sequences (T1- and T2-weighted and FLAIR imaging, performed after one month).

Recently, it has been shown that chronic relatively small (<20 mm) cerebellar cortical infarctions (based on diffusion-weighted imaging) were frequently observed in acute stroke patients, especially in case of cardioembolic stroke (with chronic small cerebellar cortical infarctions observed in 32% of cases). The high prevalence of these chronic small cerebellar cortical infarctions suggest a possible higher detection rate of chronic small-sized infarction in the cerebellum compared to the supratentorial brain.

Enrollment: 59 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients admitted to our stroke centre between February 2021 and June 2023 with the following inclusion criteria:

• age >18 years,
• initial MRI performed within one week after symptom onset,
• symptomatic brain infarction confirmed by DWI,
• presence of acute cerebral and/or cerebellar CMI

Exclusion criteria

• age < 18 years

Trial design

59 participants in 1 patient group

acute cerebral and/or cerebellar CMI

Description:

Patients with acute cerebral and/or cerebellar CMI

Treatment:

Other: None, purely observational study