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Sensory-cognitive and Physical Fitness Training in Mild Cognitive Impairment

U

University of Konstanz

Status

Completed

Conditions

Mild Alzheimer's Disease
Mild Cognitive Impairment (MCI)

Treatments

Other: auditory discrimination training
Other: physical movement training

Study type

Interventional

Funder types

Other

Identifiers

NCT01061489
WIN-Kol-09

Details and patient eligibility

About

Age-related cognitive decline is unavoidable. However, recent results of neuroplasticity-based research show that neuroplasticity-based training and physical activity might have the potential to decelerate or even reverse effects of aging and age-related cognitive impairments. Little is known whether these results also apply to pathological processes of aging such as mild cognitive impairment (MCI) and dementia.

This multi-center study aims at investigating efficiency and feasibility of a neuroplasticity-based auditory discrimination training and a physical fitness training for patients suffering from mild cognitive impairment or mild Alzheimer's disease (Mini Mental State Examination, MMSE > 19). Evaluation will include neuropsychological testing, electroencephalography (EEG) and magnetic resonance imaging (MRI) measurements as well as blood and liquor analyses.

Enrollment

65 patients

Sex

All

Ages

55+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • focus: subjective and/or objective memory complaints with MMSE > 19 (MCI or mild Alzheimer's Disease, with stable medication for at least 3 months)
  • mild to moderate depression
  • corrected-to-normal hearing and vision
  • for MRI: non-magnetic metals inside the body
  • right handedness preferred

Exclusion criteria

  • cognitive impairment/ dementia with MMSE < 20, severe psychiatric or neurological disease (current and lifetime)
  • physical health that does not allow physical fitness tests and trainings
  • benzodiazepin, tricyclic antidepressants
  • for MRI: magnetic metal inside the body, cardiac pacemaker etc.
  • for liquor: insufficient blood coagulation, insufficient brain pressure

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

65 participants in 3 patient groups

sensory-cognitive training
Experimental group
Treatment:
Other: auditory discrimination training
physical fitness
Experimental group
Treatment:
Other: physical movement training
waiting list (control group)
No Intervention group

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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