Sensory Examination and Pharmacological Modulation of Oral Hyperexcitability in Patients With Atypical Odontalgia and Matched Healthy Controls

University of Aarhus

Status and phase: Completed; Phase 4

Conditions: Odontalgia

Treatments: Drug: fentanyl; Drug: S-ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT00115102

AO1

Details and patient eligibility

About

This project examines experimental pain and chronic pain in the mouth, specifically the condition called atypical odontalgia (AO:atypical toothpain). In 16 patients with AO and 16 healthy persons, capsaicin (chili-pepper) is applied to the gingiva to cause pain. This pain is evaluated by the participants. In three sessions, 3 different medications are tested for effect on the pain. The medications are fentanyl, S-ketamine and placebo-treatment (saline). The aim is to know more about pain mechanisms in AO in order to develop an effective treatment.

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Atypical odontalgia

Exclusion criteria

• BMI > 30
• Heart conditions
• Lung disease
• Diseases of the liver or kidneys
• Hypertension, untreated

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind