Sensory Memory in Speech Motor Learning

Yale University

Status: Terminated

Conditions: Consolidation; Speech

Treatments: Behavioral: Adaptation; Other: cTBS

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT04818268

2000025475_a

R01DC017439 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal cortex associated with somatic and auditory working memory (Brodmann area 46v) to test its involvement in learning.

Full description

This study will assess the relationship between sensory working memory and speech motor adaptation using a between subjects design. Participants will be assigned to one of two groups. Each group will undergo both auditory and somatosensory working memory tests. This will be followed by adaptation to altered auditory feedback. Using a different group of subjects, cTBS will be used to disrupt neural activity in Brodmann area 46v in ventrolateral prefrontal cortex to test its involvement in adaptation. One set of tests will focus on the effects of cTBS on both auditory and somatosensory working memory. A second set of tests will focus on the effects of cTBS on speech motor adaptation to altered auditory feedback. Both working memory and adaptation are assessed on 0 to 100 scales.

Enrollment: 120 patients

Sex: All

Ages: 21 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• right handed adults
• no known physical or neurological abnormalities

Exclusion criteria

• patients with:
• cardiac pacemaker
• surgical clips or values on the heart
• implants
• metal or metallic fragments in any part of the body
• pregnancy
• claustrophobia
• a personal or family history of epilepsy
• currently taking antipsychotic drugs
• currently taking antidepressant drugs
• currently taking antianxiety drugs
• history of concussion.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 5 patient groups

Adaptation to Altered Auditory Feedback

Experimental group

Description:

Adaptation to Altered Auditory Feedback

Treatment:

Behavioral: Adaptation

Auditory Sensory Memory

Experimental group

Description:

Auditory Sensory Memory

Treatment:

Behavioral: Adaptation

Somatosensory Sensory Memory

Experimental group

Description:

Somatosensory Sensory Memory

Treatment:

Behavioral: Adaptation

Adaptation to Altered Auditory Feedback + cTBS to 46v

Experimental group

Description:

Adaptation to Altered Auditory Feedback + cTBS to 46v

Treatment:

Other: cTBS

Behavioral: Adaptation

Sensory Memory + cTBS to 46v

Experimental group

Description:

Sensory Memory + cTBS to 46v

Treatment:

Other: cTBS

Behavioral: Adaptation