Sensory Nerve Function and Exercise Therapy Response in Chronic Low Back Pain

Ahram Canadian University

Status: Enrolling

Conditions: Chronic Low-back Pain

Treatments: Other: 12-Week Tailored Exercise Intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05972369

012/0701LBP02

Details and patient eligibility

About

This observational study aims to compare measures of sensory nerve function between chronic low back pain patients matched for baseline pain and disability levels who are then classified as responders or non-responders after completing a 12-week tailored exercise program. Measures collected include sural sensory nerve conduction, quantitative sensory testing for pressure and heat pain thresholds, and psychosocial questionnaires. It is hypothesized that baseline sensory nerve dysfunction may be associated with reduced response to exercise therapy in chronic low back pain.

Full description

While exercise is commonly prescribed for chronic nonspecific low back pain (NSLBP), patient responses are variable. Differences in baseline sensory nerve function could plausibly contribute to exercise therapy outcomes. This cross-sectional quantitative observational study will investigate if baseline sensory nerve conduction amplitudes and quantitative sensory testing (QST) pain thresholds differ between matched NSLBP patients later categorized as responders or non-responders to a 12-week standardized exercise regime. A sample of 50 NSLBP participants with matched baseline pain and disability will undergo a tailored 12-week exercise intervention and 6-month follow-up. Blinded assessors will perform post-intervention sensory nerve conduction and QST measures. It is hypothesized that exercise therapy responders will show greater improvements in sensory thresholds correlating with pain relief. Results aim to elucidate neural factors associated with long-term exercise therapy outcomes in chronic low back pain.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults ages 20-60 years
• Nonspecific chronic low back pain >3 months
• Baseline pain ≥6/10 and disability ≥40%

Exclusion criteria

• Radicular leg pain
• Prior lumbar surgery
• Serious spinal pathology

Trial design

50 participants in 2 patient groups

Exercise Responders

Description:

≥30% improvement in pain with 12 weeks of prescribed exercise

Treatment:

Other: 12-Week Tailored Exercise Intervention

Exercise Non-responders

Description:

\<30% improvement in pain with 12 weeks of prescribed exercise

Treatment:

Other: 12-Week Tailored Exercise Intervention