Sensory Symptoms in Tourette Syndrome and Obsessive-Compulsive Disorder (SenST-Plus)

Vanderbilt University Medical Center

Status: Completed

Conditions: Obsessive-Compulsive Disorder; Tourette Syndrome; Sensory Disorders

Treatments: Other: None - observational study

Study type: Observational

Funder types: Other

Identifiers

NCT04335175

200502

Details and patient eligibility

About

This study seeks to address two key questions related to sensory dysregulation in Tourette syndrome (TS) and obsessive compulsive disorder (OCD): 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what extent does sensory dysregulation affect QOL in each of these disorders? Patients with TS, patients with OCD, and healthy controls will complete an online battery of validated questionnaires assessing sensory dysregulation, psychiatric symptoms, and quality of life.

Full description

Tourette syndrome (TS) is a neurodevelopmental disorder affecting 1% of school-aged children, with one-third of patients suffering persistent tics into adulthood. Obsessive-compulsive disorder (OCD) is a common comorbidity with TS. Individuals with either TS or OCD frequently exhibit sensory dysregulation, manifesting as heightened awareness of internal and external stimuli. For patients with OCD, sensory dysregulation has been linked to obsessive-compulsive symptoms and is an important consideration in treatment strategies. Sensory dysregulation remains largely unexplored in TS, but preliminary data suggests it is dissociable from tics, linked with obsessive-compulsive symptoms, and associated with poorer quality of life (QOL). This study seeks to address two key questions related to sensory dysregulation in TS and OCD: 1) Is sensory dysregulation in OCD clinically distinct from that in TS? 2) To what extent does sensory dysregulation affect QOL in each of these disorders? To do so, we will recruit patients with TS, patients with OCD, and healthy controls to complete an online battery of validated questionnaires assessing sensory dysregulation, psychiatric symptoms, and QOL. Addressing these knowledge gaps will enhance our understanding of bothersome sensory symptoms in TS and OCD, shed light on clinical overlap and/or distinctions between these commonly co-occurring psychiatric diagnoses, and clarify QOL impact and the potential need for more direct targeting of these symptoms.

Enrollment: 250 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria for the patient groups:

• age 18 years or older
• previous diagnosis of Tourette syndrome and/or obsessive compulsive disorder

Exclusion criteria for the patient groups:

• none

Inclusion criteria for healthy controls includes:

• 18 years of age or older

Exclusion criteria for the patient groups:

• history of any neurologic or psychiatric diagnoses

Trial design

250 participants in 3 patient groups

Tourette Syndrome

Description:

Individuals previously diagnosed with Tourette syndrome (TS). Participants must be 18 years of age or older.

Treatment:

Other: None - observational study

Obsessive Compulsive Disorder

Description:

Individuals previously diagnosed with obsessive compulsive disorder (OCD). Participants must be 18 years of age or older.

Treatment:

Other: None - observational study

Healthy Controls

Description:

Individuals with no past or current neurologic or psychiatric illness. Participants must be 18 years of age or older.

Treatment:

Other: None - observational study