SEP Changes During Deep Anesthesia (SEPinBSP)

Andrea Szelenyi

Status: Unknown

Conditions: Somatosensory Evoked Potentials, and Electroencephalography

Treatments: Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT02394002

2013071151

Details and patient eligibility

About

The relation between burst and suppression periods in transcranial and direct cortical recorded EEG with cortical amplitudes median nerve somatosensory evoked potentials is studied.

60 patients are included in this study: 15 patients undergoing brain tumor surgery, 15 spine surgery (University Hospital Düsseldorf) and 30 patients during general surgical procedures (Helios Klinikum Wuppertal).

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Location Helios Klinikum Wuppertal: neurological healthy patients, which undergo an elective surgery under general anaesthesia
• Location Department of Neurosurgery, University Hospital Düsseldorf: all patients with intracranial interventions and the possibility to place a stripe electrode without complications on cortex (it is decided by the surgeon while surgery because of the situs and tumorlocation)

Exclusion criteria

• periodical consumption of drugs and pharmaceuticals which influence cortical excitability
• intraoperative contraindication for required depth of anaesthesia
• neurological pre-existing illness
• advanced hepatic insufficiency

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 3 patient groups

Brain surgery

Experimental group

Description:

Somatosensory evoked potentials in relation to anasthesia (Propofol bolus) induced burst and suppression periods in electroencephalography

Treatment:

Drug: Propofol

Spine surgery

Experimental group

Description:

Somatosensory evoked potentials in relation to anasthesia (Propofol bolus) induced burst and suppression periods in electroencephalography

Treatment:

Drug: Propofol

General surgery

Active Comparator group

Description:

Somatosensory evoked potentials in relation to anasthesia (Propofol bolus) induced burst and suppression periods in electroencephalography

Treatment:

Drug: Propofol