Separation Versus Integrated Approach in Combining ECMO With CRRT

Chulalongkorn University

Status: Enrolling

Conditions: AKI

Treatments: Device: Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy

Study type: Observational

Funder types: Other

Identifiers

NCT05036616

IRB.151/64

Details and patient eligibility

About

This investigation aims to evaluate the filter life time of CRRT membrane and complication of combining ECMO and CRRT.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. > 18 years
2. Refractory acidosis (pH<7.2 or HCO3<15)
3. Refractory volume overload
4. Refractory hyperkalemia (K>6.2mEq/L or EKG change)
5. Anuria or oliguria (urine output <0.5 mL/kg/hr for 6-12hr)
6. High BUN >100 mg/dL or uremic symptom
7. Increase intracranial pressure

Exclusion criteria

1. Pregnancy
2. Not use heparin in ECMO
3. Chronic kidney disease with CRRT
4. AKI with Glomerulonephritis, Interstitial nephritis, Vassculitis or Urinary tract obstruction

Trial design

40 participants in 2 patient groups

Separation technique

Treatment:

Device: Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy

Integration technique

Treatment:

Device: Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy