Separation Versus Integrated Approach in Combining ECMO With CRRT (E-CRRT)

Chulalongkorn University

Status: Completed

Conditions: AKI

Treatments: Device: Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05036616

IRB.151/64

Details and patient eligibility

About

This study aimed to compare circuit lifespan of CRRT between Integration and Separation techniques during ECMO support.

Enrollment: 80 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

ECMO patients >18 years old who met the KDIGO criteria for acute kidney injury and required continuous renal replacement therapy (CRRT). Inclusion criteria were as follows:

1. Refractory acidosis, defined as pH < 7.2 or serum bicarbonate (HCO₃-) < 15 mmol/L
2. Refractory volume overload
3. Refractory hyperkalemia, defined as serum potassium (K⁺) > 6.2 mEq/L or presence of electrocardiographic changes
4. Anuria or oliguria, defined as urine output < 0.5 mL/kg/hr for 6-12 hours
5. Elevated BUN >100 mg/dL or presence of uremic symptoms Increased intracranial pressure

Exclusion Criteria:

1. Pregnancy
2. Heparin contraindication
3. Chronic kidney disease with CRRT
4. AKI with Glomerulonephritis, Interstitial nephritis, Vassculitis or Urinary tract obstruction

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

Separation technique

Experimental group

Treatment:

Device: Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy

Integration technique

Experimental group

Treatment:

Device: Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy