Septal Shift for the Diagnosis of COnstrictive Pericarditis: The Impact of Inspiratory Effort Quantification on Deep Breathing Manoeuvres (SCOPED)

U

Université de Sherbrooke

Status

Unknown

Conditions

Constrictive Pericarditis

Treatments

Behavioral: Breathing

Study type

Observational

Funder types

Other

Identifiers

NCT02685371
MP-31-2016-1083

Details and patient eligibility

About

This study will evaluate the effect of deep breathing manoeuvres on inter ventricular interdependency physiology. By providing further insight in this basic physiology we want to add more comprehensive data in favor or not of constrictive pericarditis diagnostic criteria currently used in cardiovascular magnetic resonance.

Enrollment

60 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Men and women between 18 and 80 years old
  • Normal transthoracic echocardiogram if older than 41 years old
  • Normal standardized history and physical examination
  • Normal blood pressure (<130/80)
  • Normal 12-lead ECG at rest.

Exclusion criteria

  • No prior pulmonary or cardiac diseases
  • Unexplained symptoms that could be related to a heart or pulmonary problems.
  • Symptoms of or active cardiovascular or pulmonary problems
  • Hepatic or kidney dysfunction
  • Blood cell dyscrasia
  • Cardiovascular risk factor (smoking, hypertension, dyslipidemia, diabetes)
  • Obesity (BMI > 30)
  • Pregnancy or pregnancy in the last year
  • Cardiac congenital anomalies discovered during the cardiovascular magnetic resonance
  • Current medication with cardiovascular side effects known (diuretics, beta-blockers, calcium channel blockers)
  • Contraindication to cardiovascular magnetic resonance

Trial design

60 participants in 1 patient group

Breathing effort type
Description:
Current known criteria for constrictive pericarditis will be test under: 1- spontaneous breathing 2- Breathing with a negative pressure of -15 to - 30 cm of water 3- Breathing with a negative pressure of more than - 30 cm of water.
Treatment:
Behavioral: Breathing

Trial contacts and locations

1

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Central trial contact

Farand Paul, M.D.; Etienne L Couture, M.D.

Data sourced from clinicaltrials.gov

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