Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study)

University of Manitoba

Status: Completed

Conditions: Renal Failure; Delirium; Septic Shock

Treatments: Other: Observation

Study type: Observational

Funder types: Other

Identifiers

NCT01836302

B2011:138

Details and patient eligibility

About

Delirium in the ICU is a prevalent problem occurring in up to 80% of ICU patients. A potential cause of delirium in ICU patients could be cerebral hypoxia. Septic shock is associated with high rates of delirium.

The aim of this pilot study is two fold. First, to determine the feasibility and potential challenges of measuring cerebral oxygenation in ICU patients with severe sepsis and septic shock. And second, to see if the incidence and magnitude of cerebral desaturations correlated with ICU acquired delirium as measured by the Confusion Assessment Method (CAM) scores.

Enrollment: 16 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Over 18
• Diagnosis of septic shock
• Require mechanical ventilation and vasopressor therapy

Exclusion criteria

• Previous stroke
• Dementia
• Recent Craniotomy

Trial design

16 participants in 2 patient groups

Patients with Cerebral Desaturation

Description:

We will compare the primary and secondary outcomes between the patients who experience cerebral desaturations and those that do not.

Treatment:

Other: Observation

Patients without cerebral desaturation

Description:

We will compare the primary and secondary outcomes between the patients who experience cerebral desaturations and those that do not.

Treatment:

Other: Observation