Sequenced vs. Integrated Delivery of Treatment for Adolescent Depression and SUD (Sequencing)

Oregon Research Institute

Status: Completed

Conditions: Substance Use Disorders; Adolescent; Depression

Treatments: Behavioral: Adolescent Coping With Depression/Functional Family Therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT00680966

DA021357

1R01DA021357 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to determine whether it is more effective to treat adolescents, with diagnoses of both depression and substance use disorder, with a treatment addressing the substance use first and then treating the depression or to first treat the depression and then treat the substance use or whether treating both disorders simultaneously is most effective.

It is expected that treatment of both disorders at the same time will be the most effective.

Full description

Comorbidity is a well established aspect of adolescent psychopathology. The majority of adolescents entering treatment have more than one condition. This study will evaluate service delivery methods of integrating empirically supported interventions for depression and non-nicotine substance use disorders (SUD)in an effort to improve treatment engagement, response, and maintenance of gains. The two examined interventions are the Adolescent Coping With Depression course (ACWD) and Functional Family Therapy (FFT).

This study will expand upon previous research by systematically treating both depression and SUD. Over a 5 year period, 180 adolescents with depression/SUD and their parents/guardians will be recruited in Oregon and New Mexico and randomly assigned to 1 of 3 conditions: (a) FFT followed by ACWD, (b) ACWD followed by FFT, or (c) an intervention combining and augmenting FFT and ACWD (Integrated Treatment). Each treatment arm will consist of 24 sessions provided over 20 weeks. Participants will be assessed at intake, after the provision of 6, 12 (Mid-treatment), 18 and 24 (Post-treatment)treatment sessions, and at 6 and 12 month follow-ups.

Enrollment: 180 patients

Sex: All

Ages: 13 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. DSM-IV-TR diagnosis of depression, defined as MDD, dysthymia, or substance-induced mood disorder meeting MDD or dysthymia symptom criteria
2. DSM-IV-TR diagnosis of one or more non-nicotine SUD
3. Some reported illicit drug use in the last 90 days
4. 13-17 years of age
5. parent or guardian willing to participate in study
6. basic English competency (ability to converse in English)

Exclusion criteria

1. Current and acute suicidal ideation at the level warranting inpatient treatment
2. current psychotic symptoms
3. the adolescent's sibling is already participating in the study
4. if on psychiatric medications, a significant change in dosage levels in the prior 4 weeks -

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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180 participants in 3 patient groups

TX1

Experimental group

Description:

Functional Family Therapy (FFT) followed by Adolescent Coping With Depression (ACWD)

Treatment:

Behavioral: Adolescent Coping With Depression/Functional Family Therapy

TX 2

Experimental group

Description:

ACWD (Adolescent Coping With Depression) followed by FFT (Functional Family Therapy)

Treatment:

Behavioral: Adolescent Coping With Depression/Functional Family Therapy

TX 3

Experimental group

Description:

Combination of an augmented FFT and ACWD - Integrated treatment

Treatment:

Behavioral: Adolescent Coping With Depression/Functional Family Therapy