Sequential Therapy of Atorvastatin Improve Outcomes of ST-elevated Acute Myocardial Infarction

Zhang Qi, MD

Status

Unknown

Conditions

Acute Myocardial Infarction

Treatments

Drug: Sequential therapy of atorvastatin

Study type

Interventional

Funder types

Other

Identifiers

NCT01997294

RJH20130115

2011BAI11B05 (Other Grant/Funding Number)

Details and patient eligibility

About

Statins have been approved to benefit patients underwent percutaneous coronary intervention (PCI). The current study is designed to evaluate the effectiveness and safety of Sequential Therapy of Atorvastatin in patients with ST-elevated myocardial infarction and receive PCI treatment.

Enrollment

1,200 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Sighed informed consent
Diagnosised as acute myocardial infarction
Time frame less than 12 hours since the occurance of chest pain
Aggred to receive sirolimus-eluted coronary stents
Patients willing to accepte follow-up

Exclusion criteria

Allegy to statins or with a history against statin therapy
Allegy to any products that will be used during PPCI
Disagreed to receive PPCI and other related therapy
Existing sever liver dysfuntion that statins can not be used according to the guildlines
Sever kidney dysfunction (creatinine >3mg/dl or eGFR<30ml/min)
Sever left ventricular dysfunction (Killip grade 3)
Patients are currently taking medicine that may influence the use of statin
Patients with a history of alcohol abuse or durg abuse
Woman during pregnancy or lactation
Patients who has attended other clinical trials
Patients who has received PCI or CABG previously
Patients who can not agree to accept study protocol
Other conditions that may not sutible for the current study