Sequential Versus Single O2 Levels on Human Embryo Development

I

Ibn Sina Hospital

Status

Completed

Conditions

Embryo Culture

Treatments

Other: Sequential O2 Culture

Study type

Interventional

Funder types

Other

Identifiers

NCT03630900
Ibnsina IVF-Oxygen

Details and patient eligibility

About

Myriads of elements affect human embryo culture in vitro. These include, but not limited to, air quality, culture media, culture temperature, incubator humidity, pH, and O2 levels. O2 tension has been thoroughly investigated and, to date, 5% O2 level is superior to 20%. Reports showed that lowering the O2 from Day 3 of embryo culture seems to be physiological.

Enrollment

487 patients

Sex

Female

Ages

18 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

ICSI cycles undergoing their first ICSI attempt

Exclusion criteria

ICSI cycles with a previous failure

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

487 participants in 2 patient groups

Sequential O2 culture (5% then 2.5%)
Experimental group
Description:
Embryo culture from day 0 to 3 in 5% O2 then split to either 5% or 2.5% O2 until Day 5 or 6.
Treatment:
Other: Sequential O2 Culture
5% O2 culture
No Intervention group

Trial contacts and locations

3

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Data sourced from clinicaltrials.gov

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