Serial Comparisons of Abdominal and Neurological MRI Scans (SCANMRI)

University of British Columbia

Status: Unknown

Conditions: Psychotic Disorders

Study type: Observational

Funder types: Other

Identifiers

NCT02009969

H13-01685

Details and patient eligibility

About

The purpose of this study is to compare abdominal weight gain and fat distribution to changes in brain morphology in people taking antipsychotic medications.

Full description

Abdominal weight gain is a significant side effect of antipsychotic medications. It has even been suggested to be part of the pathology of severe mental illnesses. Studies have shown that in persons with bipolar disorder, increased body mass index (BMI) is associated with irregular changes in the brain. This association has not been tested in persons with psychosis. In this study, we will be measuring abdominal fat distribution as measured by MRI to see if this is associated with abnormal brain morphology.

Enrollment: 40 estimated patients

Sex: All

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Must be admitted to the BC (British Columbia) Psychosis Program at UBC (University of British Columbia) Hospital
• Must have clinically diagnosed psychosis (e.g. schizophrenia)
• Must be fluent in English
• Must not be contraindicated for MRI (i.e., must not be claustrophobic, have metal in the body, be pregnant, have BMI greater than or equal to 40, etc.)

Exclusion criteria

• None, other than those listed above