Serological Evaluation of 77A/G and 11A/12A Gene of MMP-13 in Periodontitis Affected and Healthy Individuals (SEGPPAH)

Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre

Status: Unknown

Conditions: Generalized Adult Periodontitis

Treatments: Genetic: blood samples collected from all patients

Study type: Observational

Funder types: Other

Identifiers

NCT02423304

Divya Aiswairya thesis

Details and patient eligibility

About

50 periodontitis 50 healthy individuals serological evaluation will done to see association of 77A/G AND 11A/12A gene polymorphisms of MMP-13

Full description

• The study will be conducted on 100 individuals

• 50 chronic periodontitis and 50 healthy individuals will be recruited from the Out Patient Department of Periodontics in the study.

• An informed consent will be obtained from patients who wish to participate in the study.

• Patients will be categorized by Periodontal Disease Index (PDI) by P. Ramfjord(1959)

• After clinical examination, blood samples will be collected and assessed for MMP 13 Gene Polymorphisms.

• Subjects will be selected according to the study criteria and divided into two groups (50 each).

  1. Test group
  2. Control group

Enrollment: 100 estimated patients

Sex: All

Ages: 30 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:• Test group

1. Patients with chronic periodontitis classified according to American Academy of Periodontology ( AAP) 1999

2. Subjects aged between 30-55 years

   • Control group Systemically and periodontally healthy individuals of same age group

Exclusion Criteria:

1. Present and past Smokers
2. Presence of any systemic diseases.
3. Oral diseases other than Periodontitis
4. With a previous history of periodontal treatment in the past 6 months and subjects under any medications.
5. Family history of any diagnosed genetic disorders.

Trial design

100 participants in 2 patient groups

test

Description:

50 periodontitis patients • Patients will be categorized by Periodontal Disease Index (PDI) by P. Ramfjord(1959) blood samples collected from all patients serum separated and evaluated for77A/G AND 11A/12A associated gene polymorphism of Matrix Metallo Proteinase( MMP)-13 in all the patients. studies showing that there is co relation of these genes with increase inflammation.

Treatment:

Genetic: blood samples collected from all patients

control

Description:

50 periodontally healthy individuals blood samples collected from all patients serum separated and evaluated for77A/G AND 11A/12A associated gene polymorphism of Matrix Metallo Proteinase (MMP)-13 in all the patients

Treatment:

Genetic: blood samples collected from all patients