Serotonin and the Upper Airway in Obstructive Sleep Apnea
Status and phase
Conditions
Treatments
Details and patient eligibility
About
The purpose of this study is to determine if a certain medication, alone or combined with another medication, will increase muscle activity in the upper airway in people who do and people who do not have sleep apnea. The medications being studied are paroxetine, a commonly used antidepressant, and 5 hydroxy-tryptophan (5HTP), which also can be used as a dietary supplement without a prescription. Because the effects of paroxetine in previous studies were not very large, we will also study it combined with 5HTP to see if the effect on the upper airway muscles is greater.
Sex
Ages
Volunteers
Inclusion and exclusion criteria
Group A: 20 Adult patients with mild to severe sleep apnea. If patients are being treated with nasal CPAP, they will continue treatment except on study nights.
Group B: 20 normal adult non-snoring subjects.
Trial design
Primary purpose
Allocation
Interventional model
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Trial contacts and locations
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Data sourced from clinicaltrials.gov
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