Serrated Polyp Detection Rate Between Carbon Dioxide and Air Insufflation

The Catholic University of Korea

Status: Unknown

Conditions: Serrated Polyp

Treatments: Procedure: Air insufflation colonoscopy; Procedure: Carbon dioxide insufflation colonoscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT03623906

SDR

Details and patient eligibility

About

Sessile serrated adenomas are characterized by their flat shape and the presence of a yellow mucus cap overlying the lesion. These morphological features may account for their diagnostic difficulty during colonoscopy. Missed proximal sessile serrated adenomas are regarded as an important cause for interval cancers in the right colon and emphasize the importance of developing quality measures intended to enhance their detection. There is only one single-center retrospective cohort study on the impact of carbon dioxide insufflation on the detection of serrated polyps during colonoscopy. The investigators designed a randomized, controlled trial to compare the effect of carbon dioxide insufflation vs. room air insufflation on serrated polyp detection rate.

Enrollment: 1,280 estimated patients

Sex: All

Ages: 45 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:Patients 45-75-years-old who underwent a colonoscopy -

Exclusion Criteria:polyposis syndrome, Inflammatory bowel disease, previous colorectal operation

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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1,280 participants in 2 patient groups

Carbon dioxide insufflation colonoscopy

Experimental group

Description:

Carbon dioxide insufflation colonoscopy

Treatment:

Procedure: Carbon dioxide insufflation colonoscopy

Air insufflation colonoscopy

Active Comparator group

Description:

Room air insufflation colonoscopy

Treatment:

Procedure: Air insufflation colonoscopy