Serratus Posterior Superior Intekcostal Plane Block vs Serratus Anterior Plane Block for Postoperative Analgesia in VATS: A Randomized Trial"

Samsun University

Status: Begins enrollment this month

Conditions: Postoperative Analgesia; Video Assisted Thoracoscopic Surgery

Treatments: Other: SPSIPB; Other: SAPB

Study type: Interventional

Funder types: Other

Identifiers

NCT07020624

SPSIPB

Details and patient eligibility

About

Thoracotomy is known as one of the most painful surgical procedures, with up to 65% of patients developing chronic post-thoracotomy pain syndrome (PTPS), and approximately 10% experiencing pain that significantly impacts quality of life. Video-assisted thoracoscopic surgery (VATS) has become increasingly common over the past decade and offers reduced postoperative pain, morbidity, and length of hospital stay compared to open thoracotomy. However, VATS can still cause moderate to severe postoperative pain and a high risk of chronic pain. Optimizing analgesia after VATS remains critical. With advances in ultrasound technology, several regional anesthesia techniques such as serratus anterior plane block (SAPB), erector spinae plane block (ESPB), and thoracic epidural analgesia (TEA) have shown comparable efficacy. In 2023, Tulgar et al. described the serratus posterior superior intercostal plane block (SPSIPB), which demonstrated dermatomal coverage from C3 to T10. This randomized controlled trial aims to compare the analgesic efficacy of SPSIPB and SAPB in patients undergoing VATS procedures.

Full description

The patients will be divided into two groups and all will receive general anesthesia. Before extubation, one group will receive a Serratus Anterior Plane Block, and the other group will receive a Serratus Posterior Superior Intercostal Plane Block. The randomization of the study will be performed by a physician who will not be involved in the patient follow-up, using a computer-generated randomization code (generated by the computer). The interfascial plane block (Serratus Anterior Plane Block or Serratus Posterior Superior Intercostal Plane Block) will be given to the anesthesiologist in a sealed envelope by an independent assistant personnel outside the study. The patient will not be aware of which block is being applied. The anesthesiologist performing the block will not participate in the patients' pain monitoring. Postoperative pain assessment and data collection will be performed by another anesthesiologist who is unaware of the study.

For standardization purposes, the block procedure will be performed by an experienced anesthesiologist who has performed at least 20 successful and uncomplicated procedures before.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI < 35 kg/m² Patients with ASA scores I, II, III

Exclusion criteria

• Patients who do not want to be included in the study Psychiatric and neurological disease with blurred consciousness Patients with ASA > 3 BMI > 35 kg/m² Abnormality in coagulation parameters History of allergy to local anesthetic drugs Infection at the injection site Patients whose surgical procedure time exceeds 150 minutes

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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50 participants in 2 patient groups

group serratus anterior plane block (SAP)

Active Comparator group

Description:

At the end of the surgery, ultrasound-guided serratus anterior plane block is performed with 0.25% bupivacaine. Perioperative and postoperative routine analgesic protocol is applied (consisting of intravenous analgesics and intravenous patient-controlled analgesia) without additional intervention (block) Standard Pain Monitoring and Follow-up is performed

Treatment:

Other: SAPB

group serratus posterior superior intercostal plane block(SPSIP)

Active Comparator group

Description:

At the end of the surgery, ultrasound-guided serratus posterior superior intercostal plane block is performed with 0.25% bupivacaine. Perioperative and postoperative routine analgesic protocol is applied (consisting of intravenous analgesics and intravenous patient-controlled analgesia) without additional intervention (block) Standard Pain Monitoring and Follow-up is performed

Treatment:

Other: SPSIPB