Serum Albumin Ratios Can Improve Sepsis Mortality Prediction

Benha University

Status: Completed

Conditions: Sepsis

Treatments: Drug: Blood Lactate; Diagnostic Test: C-Reactive Protein; Diagnostic Test: serum albumin; Diagnostic Test: Serum procalcitonin

Study type: Observational

Funder types: Other

Identifiers

NCT06640504

Rc 4-9-2024

Details and patient eligibility

About

Sepsis remains a leading cause of mortality in hospitalized patients, despite advancements in critical care. Existing clinical scores for predicting sepsis outcomes often lack generalizability and complexity, hindering accurate risk assessment and timely intervention. This study aimed to evaluate the prognostic performance of serum albumin ratios to C-reactive protein (CRP), procalcitonin (PCT), and lactate in predicting 28-day morbidities and mortality in sepsis patients admitted to surgical ICUs. By incorporating these albumin ratios into clinical decision-making, we hypothesized that clinicians could more accurately identify patients at high risk of adverse outcomes and tailor treatment strategies accordingly.

Enrollment: 30 patients

Sex: All

Ages: 12 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients newly admitted to ICU with sepsis or septic shock;
• Patients were free of exclusion criteria.

Exclusion criteria

• Patients with acute kidney injury;
• Patients with hemorrhagic shock;
• Patients with immunosuppressive or autoimmune disorders;
• Patients suspected to die in ICU.

Trial design

30 participants in 1 patient group

Group 1

Description:

Patients newly admitted to ICU with sepsis or septic shock with manifestations suggestive of sepsis according to the guidelines of the 3rd International consensus definitions for sepsis and septic shock.

Treatment:

Diagnostic Test: Serum procalcitonin

Diagnostic Test: serum albumin

Diagnostic Test: C-Reactive Protein

Drug: Blood Lactate