Serum and Peritoneal CEA and CA 19-9 for Gastric Adenocarcinoma

Bezmialem Vakif University

Status: Completed

Conditions: Gastric Adenocarcinoma

Treatments: Procedure: gastrectomy; Procedure: sampling of peritoneal washing aspirate

Study type: Observational

Funder types: Other

Identifiers

NCT02801955

GastCancTmMark2016

Details and patient eligibility

About

For preoperative staging and prediction of peritoneal dissemination of gastric adenocarcinoma, usage of serum and peritoneal levels of carcinoembryonic antigen (CEA) and CA 19-9 may be helpful. Additionally, the prognosis of the patients with gastric adenocarcinoma treated with gastrectrectomy may be associated with serum and peritoneal levels of tumor markers.

Full description

Clinical usage of tumor markers on preoperative staging and prediction of peritoneal dissemination of gastric adenocarcinoma is a controversial issue. It has been thought that there is a positive correlation between serum and peritoneal levels of carcinoembryonic antigen (CEA) and CA 19-9 and pathologic features of gastric tumors and peritoneal dissemination.

In this study, it was aimed to evaluate the effect of serum and peritoneal CEA and CA 19-9 to predict TNM stages and peritoneal washing cytology in patients with gastric adenocarcinoma after curative gastrectomy, and to determine predictive value of these measurements to the development of recurrence and death.

Enrollment: 67 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Endoscopically proven gastric adenocarcinoma
• Standard gastrectomy and a D2 lymph node dissection;
• Desire to attend the study protocol

Exclusion criteria

• Metastatic or overt peritoneal disseminated cancer
• Undesired reaction to attend the study protocol

Trial design

67 participants in 1 patient group

tumor marker

Description:

serum CEA and CA 19-9 levels in patients with curative gastrectomy preoperatively and peritoneal CEA and CA 19-9 levels in patients taken at the beginning of curative gastrectomy via sampling of peritoneal washing aspirate

Treatment:

Procedure: gastrectomy

Procedure: sampling of peritoneal washing aspirate