Serum and Urine Metabolome Studies in Patients With Acute Kidney Injury After Cardiac Surgery

Nanjing Medical University

Status: Active, not recruiting

Conditions: Cardiac Surgery Associated Acute Kidney Injury

Study type: Observational

Funder types: Other

Identifiers

NCT06245720

KY20240123-01

Details and patient eligibility

About

The goal of this observational study is to learn about serum and urine metabolome in patients after cardiac surgery.

Full description

The main objective of this study is to collect blood and urine samples from patients after cardiac surgery, and to perform metabolomic analysis to find the differential metabolites and their enrichment pathways in AKI patients and non-AKI patients.The secondary objective is to intervene in its enrichment pathway to find ways to improve CSA-AKI.

Enrollment: 200 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age> 18 years old;
2. after cardiopulmonary bypass;

Exclusion criteria

1. Under the age of 18;
2. Previous chronic kidney disease or receiving renal replacement therapy;
3. Have a history of kidney transplantation or nephrectomy.

Trial design

200 participants in 2 patient groups

AKI group

Description:

AKI is then defined as an increase in serum creatinine (SCr) of at least 26.4 μmol/L over 48 hours, or an increase in SCr greater than 1.5 times baseline over 7 days, or a urine output of less than 0.5 mL/kg per hour for more than 6 hours, according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines.

Non-AKI group

Description:

According to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, patients do not develop acute kidney injury.