Serum Antimullerian Hormone Levels Among Epileptic Patients

Near East University, Turkey

Status: Completed

Conditions: Epilepsy; Reproductive Issues

Treatments: Diagnostic Test: serum antimullerian hormone

Study type: Interventional

Funder types: Other

Identifiers

NCT05066360

AMH

Details and patient eligibility

About

The production of AMH starts in granulosa cells before birth and the levels within the serum decreases towards the menapouse. The levels of AMH do not change throughout the menstruation cycle hovewer, it can be affected in cases related to body mass index (BMI), polycyctic ovarian syndrome (PCOS). The lower levels of AMH had been documented after ovarian surgery, radiotheraphy and chemotheraphy. AMH is a member of Transforming Growth Faktor β (TGF- β ) and it has receptors in brain structures including hyppocammpus. It is highly active neurophysiologically and it has a protective effect against N-methyl-D -aspartate related neuronal injury that is demonstrated both in vivo and in vitro studies. As a result, being a neuroactive hormone; AMH may have an effect on seizures within epileptic patients or serum AMH levels may be effected in epileptic patients when compared with healthy ones.

Enrollment: 60 patients

Sex: Female

Ages: 12 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy and epileptic volunteer females
• Ages between 12-18
• After menarche

Exclusion criteria

• ovarian surgery,
• history of radiotherapy
• history of chemotherapy,
• before menarche

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

participants with epilepsy

Other group

Description:

healthy, menstruating females between 12-18 ages

Treatment:

Diagnostic Test: serum antimullerian hormone

healthy participants

Other group

Description:

epileptic, menstruating females between 12-18 ages

Treatment:

Diagnostic Test: serum antimullerian hormone