Serum-Ascites Albumin Gradient Analysis in Cancer Patients in Palliative Care (AGASA-SP)

Institut Paoli-Calmettes

Status: Unknown

Conditions: Solid Cancer in a Palliative Situation With Ascites

Treatments: Diagnostic Test: serum albumin; Diagnostic Test: cirrhotic albumin

Study type: Observational

Funder types: Other

Identifiers

NCT03463655

AGASA-SP-IPC 2017-004

Details and patient eligibility

About

Current recommendations do not recommend the concomitant administration of albumin after ascites puncture in patients with ascites neoplasia unlike cirrhotic ascites. The etiology of ascites in cancer patients is multifactorial, particularly by hepatic invasion that can lead to ascites loaded with albumin. Ascites punctures therefore lead to undernutrition, recurrent early ascites by decreasing the oncotic pressure by hypo albuminemia and a state of anasarca affecting the quality of life.

Full description

According to the recommendations, each ascites fluid must be sent for biochemical and bacteriological analysis.

Demonstrate the high gradient proportion (percent only, no threshold of significance required). The literature has already validated the importance of supplementing albumen with cirrhotic ascites. Demonstrating that some cancer patients have high gradients, this will be enough to make the practitioner think to supplement.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient over 18 years of age followed for a solid cancer in a palliative metastatic situation who had a puncture of ascites.

Exclusion criteria

• Minor patient
• Known cirrhosis

Trial design

50 participants in 1 patient group

solid cancer in a palliative situation with ascites

Description:

Patient over the age of 18, followed for a solid cancer in a palliative metastatic situation, having had a puncture of ascites.

Treatment:

Diagnostic Test: serum albumin

Diagnostic Test: cirrhotic albumin